Podocyte endowment and the impact of adult body size on kidney health

Author:

Cullen-McEwen Luise A.1ORCID,van der Wolde James1,Haruhara Kotaro12,Tribolet Leon13,Dowling John P.4,Bertram Michael G.56,de Matteo Robert1,Haas Fabian7,Czogalla Jan7,Okabayashi Yusuke27,Armitage James A.8,Black M. Jane1,Hoy Wendy E.9ORCID,Puelles Victor G.17,Bertram John F.1

Affiliation:

1. Stem Cells and Development Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia

2. Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan

3. Health and Biosecurity, CSIRO, Geelong, Victoria, Australia

4. Department of Anatomical Pathology, Monash Medical Centre, Clayton, Victoria, Australia

5. Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, Umea, Sweden

6. School of Biological Sciences, Monash University, Melbourne, Victoria, Australia

7. III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

8. School of Medicine (Optometry) and Institute for Mental and Physical Health and Clinical Translation, Deakin University, Waurn Ponds, Victoria, Australia

9. Centre for Chronic Disease, University of Queensland, Royal Brisbane and Women’s Hospital, Herston, Queensland, Australia

Abstract

The present study shows, for the first time, that low birth weight as a result of maternal nutrition is associated with low podocyte endowment. However, a mild podocyte deficit at birth did not result in glomerular pathology in adulthood. In contrast, postnatal podocyte loss in combination with excessive body weight led to albuminuria and glomerulosclerosis. Taken together, these findings provide new insights into the associations between birth weight, podocyte indexes, postnatal weight, and glomerular pathology.

Funder

Department of Health, Australian Government | National Health and Medical Research Council

Publisher

American Physiological Society

Subject

Physiology

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