A new view of macula densa cell microanatomy

Author:

Gyarmati Georgina1,Shroff Urvi Nikhil1,Riquier-Brison Anne1,Kriz Wilhelm2,Kaissling Brigitte3,Neal Christopher R.4,Arkill Kenton P.5,Ahmadi Nariman6,Gill Inderbir S.6,Moon Ju-Young1,Desposito Dorinne1,Peti-Peterdi János1

Affiliation:

1. Departments of Physiology and Neuroscience, and Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California

2. Centre for Biomedicine and Medical Technology Mannheim, Neuroanatomy, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

3. Institute of Anatomy, University of Zurich, Zurich, Switzerland

4. Bristol Renal, Bristol Heart Institute, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

5. Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute, University Park, United Kingdom

6. Institute of Urology, Catherine & Joseph Aresty Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California

Abstract

This study illuminated a physiologically regulated dense network of basal cell major and minor processes (maculapodia) in macula densa (MD) cells. The newly identified dynamic and secretory features of these microanatomical structures suggest the presence of novel functional and molecular pathways of cell-to-cell communication in the juxtaglomerular apparatus between MD and other target cells. Detailed characterization of the function and molecular details of MD cell intercellular communications and their role in physiology and disease warrant further studies.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | NIH Office of the Director

American Heart Association

Société Francophone du Diabète

British Heart Foundation

UKRI | Medical Research Council

Publisher

American Physiological Society

Subject

Physiology

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