Collecting duct water permeability inhibition by EGF is associated with decreased cAMP, PKA activity, and AQP2 phosphorylation at Ser<sup>269</sup>-Reference-Cited by-同舟云学术

Collecting duct water permeability inhibition by EGF is associated with decreased cAMP, PKA activity, and AQP2 phosphorylation at Ser²⁶⁹

Published:2024-03-01 Issue:3 Volume:326 Page:F545-F559
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Chou Chung-Lin¹^ORCID,Limbutara Kavee¹^ORCID,Kao Anika R.¹,Clark Jevin Z.¹,Nein Ellen H.¹,Raghuram Viswanathan¹,Knepper Mark A.¹^ORCID

Affiliation:

1. Epithelial Systems Biology Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States

Abstract

The authors used native rat collecting ducts to show that inhibition of vasopressin-stimulated water permeability by epidermal growth factor involves a reduction of aquaporin 2 phosphorylation at Ser269, a consequence of reduced cAMP production and PKA activity.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00197.2023

Reference78 articles.

1. PKA‐independent vasopressin signaling in renal collecting duct

2. Phosphoproteomic identification of vasopressin V2 receptor-dependent signaling in the renal collecting duct

3. Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin

4. Vasopressin-stimulated Increase in Phosphorylation at Ser269 Potentiates Plasma Membrane Retention of Aquaporin-2

5. Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct

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