Hypoxia-inducible factor protects against acute kidney injury via the Wnt/β-catenin signaling pathway-Reference-Cited by-同舟云学术

Hypoxia-inducible factor protects against acute kidney injury via the Wnt/β-catenin signaling pathway

Published:2022-06-01 Issue:6 Volume:322 Page:F611-F624
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Xu Zhi-Hui¹,Wang Chang¹²,He Yi-Xin¹,Mao Xin-Yue²,Zhang Man-Zhu²,Hou Yan-Pei¹,Li Bing¹²^ORCID

Affiliation:

1. Department of Nephrology, 2nd Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China

2. Department of Nephrology, Institute of Nephrology, 2nd Affiliated Hospital of Hainan Medical University, Haikou, People’s Republic of China

Abstract

We investigated the role of hypoxia-inducible factor (HIF) in acute kidney injury in vivo and in vitro. Expression of HIF in the adaptive repair group was more rapid and sufficient than that in the maladaptive repair group during the early repair phase. HK-2 and EA.hy926 cells treated with hypoxia/reoxygenation were used to elucidate the cross talk between HIF and the Wnt/β-catenin signaling pathway by which HIF played a renoprotective role in acute kidney injury.

Funder

Key Research and Development Project of Hainan Province

National Natural Science Foundation of China

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00023.2022

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