Bone loss after severe spinal cord injury coincides with reduced bone formation and precedes bone blood flow deficits-Reference-Cited by-同舟云学术

Bone loss after severe spinal cord injury coincides with reduced bone formation and precedes bone blood flow deficits

Published:2021-10-01 Issue:4 Volume:131 Page:1288-1299
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Yarrow Joshua F.¹²³^ORCID,Wnek Russell D.¹,Conover Christine F.¹,Reynolds Michael C.¹,Buckley Kinley H.¹,Kura Jayachandra R.¹,Sutor Tommy W.¹,Otzel Dana M.²,Mattingly Alex J.⁴,Croft Summer⁵,Aguirre J. Ignacio⁵,Borst Stephen E.¹,Beck Darren T.⁶,McCullough Danielle J.⁶

Affiliation:

1. Research Service, Malcom Randall Department of Veterans Affairs Medical Center, North Florida/South Georgia Veterans Health System, Gainesville, Florida

2. Brain Rehabilitation Research Center, Malcom Randall Department of Veterans Affairs Medical Center, North Florida/South Georgia Veterans Health System, Gainesville, Florida

3. Division of Endocrinology, Diabetes, and Metabolism, University of Florida College of Medicine, Gainesville, Florida

4. Geriatrics Research, Education, and Clinical Center, North Florida/South Georgia Veterans Health System, Gainesville, Florida

5. Department of Physiological Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida

6. Department of Cell Biology and Physiology, Edward Via College of Osteopathic Medicine—Auburn Campus, Auburn, Alabama

Abstract

We provide the first direct evidence indicating femur and tibia blood flow (BF) deficits exist in conscious (awake) rats after severe contusion spinal cord injury (SCI), with the distal femur displaying the largest BF deficits. Reduced bone perfusion temporally coincided with unopposed bone resorption, as indicated by ongoing osteoclast-mediated bone resorption and a near absence of surface-level bone formation indices, which resulted in severe cancellous and cortical microstructural deterioration after SCI.

Funder

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00444.2021

Reference50 articles.

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2. Bone and muscle loss after spinal cord injury: organ interactions

3. Difference in intraosseous blood vessel volume and number in osteoporotic model mice induced by spinal cord injury and sciatic nerve resection

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