Passive bicycle training stimulates epiphyseal bone formation and restores bone integrity independent of locomotor recovery in a rat spinal cord injury model-Reference-Cited by-同舟云学术

Passive bicycle training stimulates epiphyseal bone formation and restores bone integrity independent of locomotor recovery in a rat spinal cord injury model

Published:2024-09-01 Issue:3 Volume:137 Page:676-688
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Kura Jayachandra R.¹,Cheung Bosco¹,Conover Christine F.¹,Wnek Russell D.¹,Reynolds Michael C.¹,Buckley Kinley H.¹,Soto Benjamin M.¹,Otzel Dana M.¹,Aguirre J. Ignacio²,Yarrow Joshua F.¹³⁴⁵^ORCID

Affiliation:

1. Malcom Randall Department of Veterans Affairs Medical Center, Brain Rehabilitation Research Center, North Florida/South Georgia Veterans Health System, Gainesville, Florida, United States

2. Department of Physiological Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, United States

3. Division of Endocrinology, Diabetes, and Metabolism, University of Florida College of Medicine, Gainesville, Florida, United States

4. Eastern Colorado Geriatrics Research, Education, and Clinical Service, Rocky Mountain Regional VA Medical Center, VA Eastern Colorado Health Care System, Aurora, Colorado, United States

5. Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

Abstract

This study was the first to assess how quadrupedal bodyweight-supported treadmill training or passive isokinetic bicycle (cycle) training impacts bone recovery at the distal femoral and proximal tibial epiphyses in a rat model of severe contusion spinal cord injury. Our results demonstrate that passive isokinetic cycle training completely restored cancellous and cortical bone microstructural parameters at these sites via osteoblast-mediated bone anabolic actions, independent of locomotor recovery or increased plantar flexor muscle mass.

Funder

American Physiological Society

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00299.2024

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