The nitric oxide dependence of cutaneous microvascular function to independent and combined hypoxic cold exposure

Author:

Arnold Josh T.1ORCID,Lloyd Alex B.1ORCID,Bailey Stephen J.2,Fujimoto Tomomi345,Matsutake Ryoko5,Takayanagi Masataka5,Nishiyasu Takeshi5,Fujii Naoto5ORCID

Affiliation:

1. Environmental Ergonomics Research Centre, Loughborough University, Loughborough, United Kingdom

2. School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom

3. Department of Health and Sports, Niigata University of Health and Welfare, Niigata, Japan

4. Institute for Human Movement and Medical Science, Niigata University of Health and Welfare, Niigata, Japan

5. Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan

Abstract

When separated from local cooling, whole body cooling elicited cutaneous reflex vasoconstriction via mechanisms independent of nitric oxide removal. Hypoxia elicited cutaneous vasodilatation via mechanisms mediated primarily by nitric oxide synthase, rather than xanthine oxidase-mediated nitrite reduction. Cold-induced vasoconstriction was blunted by the opposing effect of hypoxic vasodilatation, whereas the underpinning mechanisms did not interrelate in the absence of local cooling. Full vasoconstriction was restored with nitric oxide synthase inhibition.

Funder

Japan Society for the Promotion of Science London

Japan Society for the Promotion of Science

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3