A novel animal model to study delayed resuscitation following traumatic hemorrhage

Author:

Xiang Lusha1ORCID,Calderon Alfredo S.1,Klemcke Harold G.1ORCID,Hinojosa-Laborde Carmen1ORCID,Becerra Sandra C.1,Ryan Kathy L.1

Affiliation:

1. U.S. Army Institute of Surgical Research, JBSA-Fort Sam Houston, San Antonio, Texas

Abstract

A focus of combat casualty care research is to develop treatment where full resuscitation after hemorrhage is delayed. However, animal models of combat-related hemorrhagic shock in which to determine physiological outcomes of such delays and explore potential treatment for golden hour extension are lacking. In this study, we filled this knowledge gap by establishing a traumatic shock model with reproducible development of AKI and shock-related complications determined by the time of resuscitation.

Funder

DOD | United States Army | MEDCOM | U.S. Army Medical Research and Development Command

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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