Maternal use of electronic cigarettes and impact on offspring: a double-hit model

Author:

Mills Amber12ORCID,Velayutham Murugesan234,Corbin Debbie5,Suter Lindsey6,Robinson Madison6,Khramtsov Valery V.34ORCID,Shouldis Lainey7,Cook Mary6,Dakhallah Duaa8,Chantler Paul D.65ORCID,Olfert I. Mark126ORCID

Affiliation:

1. Department of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, Morgantown, West Virginia, United States

2. Center for Inhalation Toxicology, West Virginia University School of Medicine, Morgantown, West Virginia, United States

3. In vivo Multifunctional Magnetic Resonance (IMMR) Center, West Virginia University School of Medicine, Morgantown, West Virginia, United States

4. Department of Biochemistry and Molecular Medicine, West Virginia University School of Medicine, Morgantown, West Virginia, United States

5. Department of Neuroscience, West Virginia University School of Medicine, Morgantown, West Virginia, United States

6. Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, West Virginia, United States

7. Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, West Virginia, United States

8. Department of Surgery, West Virginia University School of Medicine, Morgantown, West Virginia, United States

Abstract

These data add to the growing body of literature demonstrating that electronic cigarette (Ecig) use during pregnancy (even without nicotine) is not safe, and primes offspring to have worse cardiovascular health outcomes in early and adult life. A key finding from this work is that a second insult from direct vaping in offspring with prior in utero exposure induces greater vascular dysfunction, increased oxidative stress, and shows evidence of neuronal dysfunction compared with either direct- or maternal-only exposure.

Funder

American Heart Association

HHS | NIH | National Institute of Environmental Health Sciences

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Physiological Society

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