Maternal electronic cigarette use during pregnancy affects long-term arterial function in offspring

Author:

Aboaziza Eiman12ORCID,Feaster Kimberly3,Hare Lance2,Chantler Paul D.124ORCID,Olfert I. Mark1245ORCID

Affiliation:

1. West Virginia Clinical and Translational Science Institute, West Virginia University School of Medicine, Morgantown, West Virginia

2. WVU Center of Inhalation Toxicology, West Virginia University School of Medicine, Morgantown, West Virginia

3. Department of Pathology, Anatomy and Laboratory Medicine, West Virginia University School of Medicine, Morgantown, West Virginia

4. Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, West Virginia

5. Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia

Abstract

We observe a significant alteration in arterial structure and function in adolescent and adult offspring due to developmental exposure to toxicants resulting from perinatal maternal vaping. Taken together with previous work that described lasting dysfunction in cerebral microvasculature in offspring, these data underscore the adverse consequences of maternal exposure to electronic cigarette aerosol in conduit and resistance vessels alike, irrespective of nicotine content.

Funder

American Heart Association

HHS | NIH | National Institute of General Medical Sciences

West Virginia University

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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