A chronic high-fat diet exacerbates contractile dysfunction with impaired intracellular Ca2+ release capacity in the skeletal muscle of aged mice

Author:

Eshima Hiroaki123,Tamura Yoshifumi12,Kakehi Saori12,Kakigi Ryo4,Hashimoto Ryota4,Funai Katsuhiko3,Kawamori Ryuzo12,Watada Hirotaka1256

Affiliation:

1. Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan

2. Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan

3. Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, Utah

4. Department of Physiology, Juntendo University Faculty of Medicine, Tokyo, Japan

5. Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan

6. Center for Molecular Diabetology, Juntendo University Graduate School of Medicine, Tokyo, Japan

Abstract

The aim of this study was to examine the effect of high-fat diet (HFD)-induced obesity on contractile function and Ca2+ release capacity in aged skeletal muscle. Not only were the force production and peak Ca2+ levels decreased by aging and HFD feeding, respectively, but also, these interventions had an additive effect in aged HFD-fed mice. These data suggest that the impairment in the contractile force in aged muscle is aggravated by a HFD, which may be due to synergistic dysfunction in intracellular Ca2+ release.

Funder

Strategic Research Foundation at Private University

KAKENHI

Suzuken Memorial Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3