A chronic high‐fat diet does not exacerbate muscle atrophy in fast‐twitch skeletal muscle of aged mice

Author:

Tagawa Tsutomu1,Eshima Hiroaki123,Kakehi Saori23,Kawamori Ryuzo23,Watada Hirotaka2345,Tamura Yoshifumi23ORCID

Affiliation:

1. Department of International Tourism Nagasaki International University Nagasaki Japan

2. Department of Metabolism & Endocrinology Juntendo University Graduate School of Medicine Tokyo Japan

3. Sportology Center Juntendo University Graduate School of Medicine Tokyo Japan

4. Center for Therapeutic Innovations in Diabetes Juntendo University Graduate School of Medicine Tokyo Japan

5. Center for Identification of Diabetic Therapeutic Targets Juntendo University Graduate School of Medicine Tokyo Japan

Abstract

AbstractObesity and ageing reduce muscle mass and lead to deficits in muscle maintenance, but it is not known whether obesity accelerates muscle wasting additively in the setting of ageing. We investigated morphological characteristics in fast‐twitch extensor digitorum longus (EDL) muscle of mice fed a low‐fat diet (LFD) or a high‐fat diet (HFD) for 4 or 20 months. The fast‐twitch EDL muscle was harvested, and the muscle fibre‐type composition, individual muscle cross‐sectional area and myotube diameter were measured. We found an increase in the percentage of type IIa and IIx myosin heavy chain fibres in the whole EDL muscle, but a decrease in type IIB myosin heavy chain in both HFD protocols. The cross‐sectional area and myofibre diameter were lower in both groups of aged mice (after 20 months of LFD or HFD) compared with young mice (after 4 months of the diets), but there were no differences between mice fed LFD or HFD for 20 months. These data suggest that long‐term feeding of HFD does not aggravate muscle wasting in fast‐twitch EDL muscle of male mice.

Publisher

Wiley

Subject

Physiology,Physiology (medical),Nutrition and Dietetics,Physiology,Physiology (medical),Nutrition and Dietetics

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