Turning lung clearance index on its head. Reference data for SF6 multiple-breath washout derived ventilation distribution efficiency

Author:

Sandvik Rikke Mulvad1ORCID,Lindblad Anders23,Robinson Paul D.456ORCID,Nielsen Kim G.17,Gustafsson Per38

Affiliation:

1. Department of Paediatric and Adolescent Medicine, CF Centre Copenhagen, Danish Paediatric Pulmonary Service, Copenhagen University Hospital, Copenhagen, Denmark

2. Department of Pediatrics, Queen Silvia Children’s Hospital, West Sweden CF Center, Gothenburg, Sweden

3. The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

4. Department of Respiratory Medicine, The Children’s Hospital at Westmead, Sydney, New South Wales, Australia

5. The Discipline of Paediatrics and Child Health, The University of Sydney, Sydney, New South Wales, Australia

6. Airway Physiology and Imaging Group, The Woolcock Medical Research Institute, Sydney, New South Wales, Australia

7. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

8. Department of Pediatrics, General Hospital, Skövde, Sweden

Abstract

Lung clearance index (LCI) is the most used outcome from the multiple-breath washout test. As known for decades, the LCI is not linearly related to dead space ventilation, giving difficulties interpreting changes over time and in clinical trials. We present a new and improved outcome based on LCI, the ventilation distribution efficiency (VDE), which solves this problem by being linearly related to dead space ventilation. A pediatric age range reference equation for VDE is presented.

Funder

Rigshospitalet

Tømrermester Jørgen Holm og Hustru Elisa F. Hansen's Mindelegat

Vertex

Skaraborg Hospital

SAKS Research Foundation

Children's Lung Foundation, Denmark

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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