Thiamine treatment preserves cardiac function against ischemia injury via maintaining mitochondrial size and ATP levels-Reference-Cited by-同舟云学术

Thiamine treatment preserves cardiac function against ischemia injury via maintaining mitochondrial size and ATP levels

Published:2021-01-01 Issue:1 Volume:130 Page:26-35
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Yamada Yuki¹,Kusakari Yoichiro¹^ORCID,Akaoka Munetoshi¹,Watanabe Masato¹,Tanihata Jun¹,Nishioka Naritomo¹,Bochimoto Hiroki¹^ORCID,Akaike Toru¹,Tachibana Toshiaki²,Minamisawa Susumu¹^ORCID

Affiliation:

1. Department of Cell Physiology, The Jikei University School of Medicine, Tokyo, Japan

2. Division of Molecular Cell Biology, Core Research Facilities for Basic Science, The Jikei University School of Medicine, Tokyo, Japan

Abstract

We found that treatment with thiamine can have a protective effect on myocardial ischemia. Thiamine likely mediates mitochondrial fission through the inhibition of DRP1 phosphorylation and the preservation of larger-sized mitochondria and ATP concentration, leading to higher cardiac contractility performance during the subsequent reperfusion state.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00578.2020

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