Thiamine treatment preserves cardiac function against ischemia injury via maintaining mitochondrial size and ATP levels-Reference-Cited by-同舟云学术

Thiamine treatment preserves cardiac function against ischemia injury via maintaining mitochondrial size and ATP levels

Published:2021-01-01 Issue:1 Volume:130 Page:26-35
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Yamada Yuki¹,Kusakari Yoichiro¹^ORCID,Akaoka Munetoshi¹,Watanabe Masato¹,Tanihata Jun¹,Nishioka Naritomo¹,Bochimoto Hiroki¹^ORCID,Akaike Toru¹,Tachibana Toshiaki²,Minamisawa Susumu¹^ORCID

Affiliation:

1. Department of Cell Physiology, The Jikei University School of Medicine, Tokyo, Japan

2. Division of Molecular Cell Biology, Core Research Facilities for Basic Science, The Jikei University School of Medicine, Tokyo, Japan

Abstract

We found that treatment with thiamine can have a protective effect on myocardial ischemia. Thiamine likely mediates mitochondrial fission through the inhibition of DRP1 phosphorylation and the preservation of larger-sized mitochondria and ATP concentration, leading to higher cardiac contractility performance during the subsequent reperfusion state.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00578.2020

Reference44 articles.

1. Geneeskundig Tijdschrift Voor Nederlandsch-Indie

2. Thiamine and Cardiovascular Disease: A Literature Review

3. Thiamine Supplementation for the Treatment of Heart Failure: A Review of the Literature

4. Thiamine Ameliorates Diabetes-Induced Inhibition of Pyruvate Dehydrogenase (PDH) in Rat Heart Mitochondria: Investigating the Discrepancy Between PDH Activity and PDH E1α Phosphorylation in Cardiac Fibroblasts Exposed to High Glucose

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Thiamine for the Treatment of Cardiac Arrest–Induced Neurological Injury: A Randomized, Blinded, Placebo‐Controlled Experimental Study;Journal of the American Heart Association;2023-04-04

2. Effect of Thiamine Pyrophosphate Upon Oxidative Brain Injury Induced by Ischemia-Reperfusion in Rats;International Journal of Pharmacology;2023-03-15

3. Buyang Huanwu Decoction Regulates Mitochondrial Dynamics and Mitigates Cerebral Ischemia-Reperfusion Injury Via Enhancing Mitochondrial Fusion;2023

4. Targeting mitochondrial dysfunction with nutrients: challenges and opportunities;Molecular Nutrition and Mitochondria;2023

5. Associations of dietary intakes of vitamins B₁ and B₃ with risk of mortality from CVD among Japanese men and women: the Japan Collaborative Cohort study;British Journal of Nutrition;2022-04-25