Role of hyperpnea in the relaxant effect of inspired CO<sub>2</sub>on methacholine-induced bronchoconstriction-Reference-Cited by-同舟云学术

Role of hyperpnea in the relaxant effect of inspired CO₂on methacholine-induced bronchoconstriction

Published:2022-05-01 Issue:5 Volume:132 Page:1137-1144
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Torchio Roberto¹,Gobbi Alessandro²³,Gulotta Carlo¹,Antonelli Andrea⁴,Dellacà Raffaele²^ORCID,Pellegrino Giulia Michela⁵⁶,Pellegrino Riccardo⁷,Brusasco Vito⁸

Affiliation:

1. Pneumologia-Fisiopatologia Respiratoria, Torino, Italy

2. TechRes Lab, Dipartimento di Bioingegneria, Politecnico di Milano, Milano, Italy

3. Restech Srl, Milano, Italy

4. Allergologia e Fisiopatologia Respiratoria, Cuneo, Italy

5. Respiratory Unit, ASST Santi Paolo e Carlo, Dipartimento Scienze della Salute, Università degli Studi di Milano, Milan, Italy

6. Casa di Cura del Policlinico, Dipartimento di Scienze Neuroriabilitative, Milano, Italy

7. Centro Medico Pneumologico Torino, Torino, Italy

8. Centro Polifunzionale di Scienze Motorie, Dipartimento di Medicina Sperimentale, Università di Genova, Genova, Italy

Abstract

The main results of the present study are as follows: 1) breathing gas mixtures containing 2% or 4% CO2significantly attenuated bronchoconstrictor responses to methacholine, not differently in healthy subjects and subjects with mild asthma, and 2) the causal inhibitory effect of CO2was significantly mediated via an indirect effect of the increment of V̇e in response to intrapulmonary hypercapnia.

Funder

Fondazione Giovanni e Annamaria Cottino

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00763.2021

Reference63 articles.

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