Acid-base balance at high altitude in lowlanders and indigenous highlanders-Reference-Cited by-同舟云学术

Acid-base balance at high altitude in lowlanders and indigenous highlanders

Published:2022-02-01 Issue:2 Volume:132 Page:575-580
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Tymko Michael M.¹²,Willie Christopher K.¹,Howe Connor A.¹,Hoiland Ryan L.¹³⁴⁵^ORCID,Stone Rachel M.⁶,Tymko Kaitlyn⁷,Tymko Courtney¹,MacLeod David⁸^ORCID,Anholm James D.⁹,Gasho Christopher⁹,Villafuerte Francisco¹⁰^ORCID,Vizcardo-Galindo Gustavo¹¹⁰,Figueroa-Mujica Romulo¹⁰,Day Trevor A.¹¹^ORCID,Bird Jordan D.¹¹,Foster Glen E.¹^ORCID,Steinback Craig D.²^ORCID,Brugniaux Julien V.¹²,Champigneulle Benoit¹²^ORCID,Stauffer Emeric¹³,Doutreleau Stephane¹²,Verges Samuel¹²^ORCID,Swenson Erik R.¹⁴^ORCID,Ainslie Philip N.¹

Affiliation:

1. Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia – Okanagan, Kelowna, British Columbia, Canada

2. Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Alberta, Canada

3. Department of Anaesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada

4. Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

5. International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada

6. Department of Kinesiology, University of Windsor, Windsor, Ontario, Canada

7. Department of Kinesiology, University of Manitoba, Winnipeg, Manitoba, Canada

8. Human Pharmacology & Physiology Lab, Duke University Medical Center, Durham, North Carolina

9. Division of Pulmonary and Critical Care, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, California

10. Laboratorio de Fisiología Comparada/Laboratorio de Fisiología del Transporte de Oxígeno, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú

11. Department of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada

12. HP2 laboratory, Univ. Grenoble Alpes, INSERM, CHU Grenoble Alpes, Grenoble, France

13. Laboratoire Interuniversitaire de Biologie de la Motricité EA7424, Université Claude Bernard Lyon 1, Villeurbann, France

14. Pulmonary and Critical Care Medicine, VA Puget Sound Health Care System, University of Washington, Seattle, Washington

Abstract

Lowlander, Andean, and Sherpa arterial blood data were combined across five independent high-altitude expeditions in the United States, Nepal, and Peru to assess acid-base status at ∼3,800, ∼4,300, and ∼5,000 m. The main finding was that Andean and Sherpa highlander populations have more acidic arterial blood, due to elevated arterial carbon dioxide and similar arterial bicarbonate compared with acclimatizing lowlanders at altitudes ≥4,300 m.

Funder

Canada Research Chairs

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00757.2021

Reference17 articles.

1. Pulmonary gas exchange at maximal exercise in Danish lowlanders during 8 wk of acclimatization to 4,100 m and in high-altitude Aymara natives

2. AltitudeOmics: The Integrative Physiology of Human Acclimatization to Hypobaric Hypoxia and Its Retention upon Reascent