Hemorheological, cardiorespiratory, and cerebrovascular effects of pentoxifylline following acclimatization to 3,800 m-Reference-Cited by-同舟云学术

Hemorheological, cardiorespiratory, and cerebrovascular effects of pentoxifylline following acclimatization to 3,800 m

Published:2024-03-01 Issue:3 Volume:326 Page:H705-H714
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Steele Andrew R.¹^ORCID,Howe Connor A.¹,Gibbons Travis D.¹²^ORCID,Foster Katharine³⁴,Williams Alexandra M.⁵^ORCID,Caldwell Hannah G.¹,Brewster L. Madden¹,Duffy Jennifer¹,Monteleone Justin A.¹,Subedi Prajan³⁴,Anholm James D.³⁴^ORCID,Stembridge Mike⁶^ORCID,Ainslie Philip N.¹,Tremblay Joshua C.⁶^ORCID

Affiliation:

1. Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia-Okanagan, Kelowna, British Columbia, Canada

2. Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, United States

3. Pulmonary and Critical Care, Veterans Affairs Loma Linda Healthcare System, Loma Linda, California, United States

4. Department of Medicine, Loma Linda University School of Medicine, Loma Linda, California, United States

5. Department of Cellular & Physiological Sciences, Faculty of Medicine, University of British Columbia, Kelowna, British Columbia, Canada

6. Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, United Kingdom

Abstract

We conducted a double-blind, placebo-controlled study on the rheological, cardiorespiratory and cerebrovascular effects of acute pentoxifylline in healthy lowlanders after 11–14 days at 3,800 m. Although red blood cell deformability was reduced and blood viscosity increased compared with low altitude, acute pentoxifylline administration had no impact on arterial blood gases, hemorheology, inflammation, cerebral blood flow, or ventilation. Pentoxifylline decreased pulmonary artery systolic pressure in female, but not male, participants.

Funder

Principal's Research Chair

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00783.2023

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