Rapid changes in transcriptomic profile and mitochondrial function in human soleus muscle after 3-day dry immersion-Reference-Cited by-同舟云学术

Rapid changes in transcriptomic profile and mitochondrial function in human soleus muscle after 3-day dry immersion

Published:2023-05-01 Issue:5 Volume:134 Page:1256-1264
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Popov Daniil V.¹²^ORCID,Makhnovskii Pavel A.¹,Zgoda Viktor G.³,Gazizova Guzel R.⁴,Vepkhvadze Tatiana F.¹²,Lednev Egor M.¹,Motanova Evgeniia S.¹⁵,Lysenko Evgeny A.¹⁶,Orlov Oleg I.¹,Tomilovskaya Elena S.¹

Affiliation:

1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia

2. Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University, Moscow, Russia

3. V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia

4. Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan, Russia

5. Department of Biomedical Sciences, University of Padua, Padua, Italy

6. Department of Biology, University of Padua, Padua, Italy

Abstract

Three-day dry immersion (a model of physical unloading) substantially changes the transcriptomic profile in the human soleus muscle, a muscle with predominantly slow-twitch fibers and strong postural function; despite this, we found no effect on the muscle proteome (highly abundant proteins). Dry immersion markedly reduces ADP-stimulated respiration; this decline is not accompanied by a decrease in the content of mitochondrial proteins/respiratory enzymes, indicating the disruption in regulation of cellular respiration.

Funder

Russian Science Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00048.2023

Reference52 articles.

1. Disuse of the musculo-skeletal system in space and on earth

2. Unilateral lower limb suspension: integrative physiological knowledge from the past 20 years (1991–2011)

3. Isokinetic Force and Work Capacity After Long-Duration Space Station Mir and Short-Term International Space Station Missions