Physiological responses of human skeletal muscle to acute blood flow restricted exercise assessed by multimodal MRI

Author:

Haddock Bryan1ORCID,Hansen Sofie K.12,Lindberg Ulrich1,Nielsen Jakob Lindberg3,Frandsen Ulrik3,Aagaard Per3,Larsson Henrik B. W.14,Suetta Charlotte12

Affiliation:

1. Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

2. Geriatric Research Unit, Bispebjerg-Frederiksberg and Herlev-Gentofte Hospitals, Copenhagen University Hospital, Copenhagen, Denmark

3. Department of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark

4. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Abstract

Acute changes in blood flow, diffusion, blood oxygenation, cross-sectional area, and the “T2 shift” are evaluated in human skeletal muscle in response to blood flow-restricted (BFR) and conventional free-flow knee extensor exercise performed in an MRI scanner. The acute physiological response to exercise was dependent on the magnitude of load and the application of BFR. Physiological variables changed markedly and established a steady state rapidly after the first of four exercise sets.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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