Hydraulic force is a novel mechanism of diastolic function that may contribute to decreased diastolic filling in HFpEF and facilitate filling in HFrEF-Reference-Cited by-同舟云学术

Hydraulic force is a novel mechanism of diastolic function that may contribute to decreased diastolic filling in HFpEF and facilitate filling in HFrEF

Published:2021-04-01 Issue:4 Volume:130 Page:993-1000
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Steding-Ehrenborg Katarina¹^ORCID,Hedström Erik¹²,Carlsson Marcus¹^ORCID,Maksuti Elira³^ORCID,Broomé Michael³,Ugander Martin⁴⁵^ORCID,Magnusson Martin⁶⁷⁸^ORCID,Smith J. Gustav⁸⁹¹⁰,Arheden Håkan¹

Affiliation:

1. Department of Clinical Sciences Lund, Clinical Physiology, Skåne University Hospital, Lund University, Lund, Sweden

2. Department of Radiology, Skåne University Hospital, Lund, Sweden

3. Department of Physiology and Pharmacology, Anaesthesiology and Intensive Care, Karolinska Institute, Stockholm, Sweden

4. Department of Clinical Physiology, Karolinska University Hospital, and Karolinska Institute, Stockholm, Sweden

5. Kolling Institute, Royal North Shore Hospital, and Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia

6. Department of Clinical Sciences Malmö, Cardiology, Lund University, Lund, Sweden

7. Department of Cardiology, Skåne University Hospital, Malmö, Sweden

8. Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden

9. Department of Clinical Sciences Lund, Cardiology, Lund University and Skåne University Hospital, Lund, Sweden

10. Lund University Diabetes Center, Lund University, Lund, Sweden

Abstract

It is a previously unrecognized physiological mechanism of the heart that diastolic filling occurs with the help of hydraulics. In patients with heart failure with preserved ejection fraction, atrial dilatation may cause the net hydraulic force to work against cardiac filling, thus further augmenting diastolic dysfunction. In contrast, it may work favorably in patients with dilated ventricles, as in heart failure with reduced ejection fraction.

Funder

Medical Faculty Lund University

Swedish Heart and Lung foundation

Swedish Research Council for Sport Sciences

Wallenberg Centre for Molecular Medicine

Swedish Olympic Committee

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00890.2020