Endothelin-1 receptor blockade does not alter the sympathetic and hemodynamic response to acute intermittent hypoxia in men-Reference-Cited by-同舟云学术

Endothelin-1 receptor blockade does not alter the sympathetic and hemodynamic response to acute intermittent hypoxia in men

Published:2022-10-01 Issue:4 Volume:133 Page:867-875
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Limberg Jacqueline K.¹²³^ORCID,Baker Sarah E.¹^ORCID,Ott Elizabeth P.²,Jacob Dain W.²,Scruggs Zachariah M.¹,Harper Jennifer L.²,Manrique-Acevedo Camila M.⁴⁵³^ORCID

Affiliation:

1. Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota

2. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri

3. Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri

4. Department of Medicine, University of Missouri, Columbia, Missouri

5. Research Service, Harry S. Truman Memorial Veterans’ Hospital, Columbia, Missouri

Abstract

Repeat exposures to low oxygen (intermittent hypoxia, IH) elicit increases in muscle sympathetic nerve activity (MSNA) and blood pressure (BP) in men. Endothelin (ET) receptor antagonists can attenuate the sympathetic and BP response to IH in rodents; whether these data translate to humans were unclear. We show acute IH results in an increase in ET-1, MSNA, and BP in healthy young men; however, the effect of IH on MSNA and BP does not occur through activation of ET-receptors in healthy young men.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute on Aging

Mayo Clinic

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00837.2021

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1. The sympathetic nervous system and obstructive sleep apnea