Endothelial-derived extracellular vesicles associated with electronic cigarette use impair cerebral microvascular cell function-Reference-Cited by-同舟云学术

Endothelial-derived extracellular vesicles associated with electronic cigarette use impair cerebral microvascular cell function

Published:2023-08-01 Issue:2 Volume:135 Page:271-278
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Cardenas Hannah L.¹,Evanoff Nicholas G.²^ORCID,Fandl Hannah K.¹^ORCID,Berry Auburn R.¹,Wegerson Kendra N.¹,Ostrander Emily I.¹,Greiner Jared J.¹,Dufresne Sheena R.³,Kotlyar Michael³,Dengel Donald R.²^ORCID,DeSouza Christopher A.¹^ORCID,Garcia Vinicius P.¹^ORCID

Affiliation:

1. Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, United States

2. School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, United States

3. Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, United States

Abstract

In the present study, we determined the effect of circulating endothelial cell-derived microvesicles (EMVs) isolated from e-cigarette users on human cerebral microvascular endothelial cells (hCMECs) nitric oxide (NO) and endothelin (ET)-1 production and tissue-type plasminogen activator (t-PA) release. EMVs from e-cigarette users reduced brain microvascular endothelial cell NO production, enhanced ET-1 production, and impaired endothelial t-PA release. EMVs are a potential mediating factor in the increased risk of stroke associated with e-cigarette use.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00243.2023

Reference42 articles.

1. Impact of Electronic Cigarettes on the Cardiovascular System

2. Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels

3. Electronic cigarette exposure disrupts blood-brain barrier integrity and promotes neuroinflammation