Ventilatory heterogeneity in the normal human lung is unchanged by controlled breathing

Author:

Prisk G. Kim1,Petersen Gregory M.1,Geier Eric T.1ORCID,Sá Rui C.1

Affiliation:

1. Department of Medicine, University of California, San Diego, California

Abstract

By using MRI-based specific ventilation imaging (SVI), we showed that the heterogeneity of specific ventilation was not different comparing free breathing and breathing with the imposition of a fixed breathing frequency of 12 breaths/min. Thus, multiple-breath washout and SVI as typically performed provide an unperturbed measure of ventilatory heterogeneity.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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