Sex-specific effects of prenatal hypoxia on the cardiac endothelin system in adult offspring-Reference-Cited by-同舟云学术

Sex-specific effects of prenatal hypoxia on the cardiac endothelin system in adult offspring

Published:2022-03-01 Issue:3 Volume:322 Page:H442-H450
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Hula Nataliia¹²³^ORCID,Vu Jennie¹^ORCID,Quon Anita²³,Kirschenman Raven²³,Spaans Floor²³,Liu Ricky¹³,Cooke Christy-Lynn M.²³,Davidge Sandra T.¹²³^ORCID

Affiliation:

1. Department of Physiology, University of Alberta, Edmonton, Canada

2. Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada

3. Women and Children’s Health Research Institute, University of Alberta, Edmonton, Canada

Abstract

We demonstrated that prenatal hypoxia (a common condition of pregnancy) can have profound differential effects on treatment strategies in adult cardiovascular disease. Our data using a rat model of prenatal hypoxia demonstrated that, as adults, although inhibition of endothelin (ET)A receptors before an ex vivo cardiac ischemic insult improved recovery in females, it strikingly prevented recovery in males. Our data indicate a sex-specific effect of prenatal hypoxia on the cardiac ET-1 system in adult offspring.

Funder

Alberta Women's Health Foundation

University of Alberta

Alberta Innovates

Gouvernement du Canada | Canadian Institutes of Health Research

Stollery Children's Hospital Foundation

Women and Children's Health Research Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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