Placenta-targeted treatment with nMitoQ prevents an endothelin receptor-A pathway cardiac phenotype observed in adult male offspring exposed to hypoxia in utero-Reference-Cited by-同舟云学术

Placenta-targeted treatment with nMitoQ prevents an endothelin receptor-A pathway cardiac phenotype observed in adult male offspring exposed to hypoxia in utero

Published:2023-07-01 Issue:1 Volume:325 Page:H136-H141
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Hula Nataliia¹²³^ORCID,Kirschenman Raven²³,Quon Anita²³^ORCID,Spaans Floor²³,Phillips Tom J.⁴,Case C. Patrick⁵,Cooke Christy-Lynn M.²³,Davidge Sandra T.¹²³^ORCID

Affiliation:

1. Department of Physiology, University of Alberta, Edmonton, Alberta, Canada

2. Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada

3. Women and Children’s Health Research Institute, University of Alberta, Edmonton, Alberta, Canada

4. Dementia Research Institute, Cardiff University, Cardiff, United Kingdom

5. Musculoskeletal Research Unit, University of Bristol, Bristol, United Kingdom

Abstract

In this follow-up study, we showed a complete lack of recovery from I/R injury after the application of an ETA receptor antagonist (ABT-627) in adult male offspring exposed to hypoxia in utero while maternal treatment with nMitoQ during prenatal hypoxia exposure prevented this effect. Our data suggest that nMitoQ treatment during hypoxic pregnancies may prevent a hypoxic cardiac phenotype in adult male offspring.

Funder

University of Alberta

Gouvernement du Canada | Canadian Institutes of Health Research

Women and Children's Health Research Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00238.2023

Reference41 articles.

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2. Maternal smoking causes fetal hypoxia: Experimental evidence

3. The adverse effect on fetal hemogram by preeclampsia: marked anisocytosis with normocytic, normochromic erythrocythemia as well as thrombocytopenia

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