Quantitative proteomic and phosphoproteomic profiling of ischemic myocardial stunning in swine-Reference-Cited by-同舟云学术

Quantitative proteomic and phosphoproteomic profiling of ischemic myocardial stunning in swine

Published:2020-05-01 Issue:5 Volume:318 Page:H1256-H1271
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Wang Xue¹²,Shen Xiaomeng²³,Weil Brian R.⁴^ORCID,Young Rebeccah F.⁵⁶,Canty John M.⁴⁷⁵⁶,Qu Jun¹²³⁸

Affiliation:

1. Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York

2. New York State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, Buffalo, New York

3. Department of Biochemistry, University at Buffalo, Buffalo, New York

4. Department of Physiology and Biophysics, University at Buffalo, Buffalo, New York

5. Clinical and Translational Research Center, University at Buffalo, Buffalo, New York

6. Division of Cardiovascular Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York

7. Veterans Affairs Western New York Healthcare System, Buffalo, New York

8. Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, New York

Abstract

We first used ion current-based proteomics and phosphoproteomics to reliably identify novel alterations in protein expression and phosphorylation contributing to contractile dysfunction, extracellular matrix (ECM) damage, and programmed cell death in stunned myocardium and developed a comprehensive swine heart-specific proteome database, which provides a valuable resource for future research in porcine models of cardiovascular diseases.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

American Heart Association

HHS | NIH | National Center for Advancing Translational Sciences

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00713.2019

Reference75 articles.