Affiliation:
1. Samara State Medical University of the Ministry of Healthcare of the Russian Federation (SamSMU)
2. Samara State Medical University of the Ministry of Healthcare of the Russian Federation (SamSMU);
Medical University “Reaviz”
Abstract
Myocardial ischemia is the basis for many acute and chronic conditions with great social significance. Therefore, experimental models that describe ischemia development in humans are necessary for a better understanding of the pathophysiology of these conditions and the development of medical and surgical methods of treatment.Aim: To compare current approaches to experimental modeling of myocardial ischemia considering the pathogenetic features of the simulated processes. The manuscript describes the main experimental models of myocardial ischemia: in vitro cellular models, ex vivo isolated heart models, in vivo animal models, the principal components of the ‘heart-on-chip’ model and the possibilities of in silico modeling. The criteria for choosing a specific model of ischemia by pathophysiological approach, advantages and limitations of the models are considered.
Publisher
Cardiology Research Institute
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