Age- and sex-related differences in sympathetic vascular transduction and neurohemodynamic balance in humans

Author:

D’Souza Andrew W.1ORCID,Hissen Sarah L.23ORCID,Manabe Kazumasa23ORCID,Takeda Ryosuke234ORCID,Washio Takuro23ORCID,Coombs Geoff B.1ORCID,Sanchez Belinda23,Fu Qi23ORCID,Shoemaker J. Kevin15ORCID

Affiliation:

1. Neurovascular Research Laboratory, School of Kinesiology, Western University, London, Ontario, Canada

2. Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, United States

3. Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, United States

4. Laboratory of Neuromuscular Biomechanics, School of Health and Sport Sciences, Chukyo University, Toyota, Japan

5. Department of Physiology and Pharmacology, Western University, London, Ontario, Canada

Abstract

Sympathetic vascular transduction is attenuated in older compared with young adults, regardless of biological sex. Males, but not females (regardless of age), demonstrate an inverse relationship between central (sympathetic baroreflex sensitivity) and peripheral (sympathetic vascular transduction) components of the baroreflex arc. Young males and older females exhibit an inverse relationship between resting sympathetic outflow and sympathetic vascular transduction. Our results indicate that age and sex exert independent and interactive effects on sympathetic vascular transduction and sympathetic neurohemodynamic balance in humans.

Funder

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Ontario, Canada

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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