Reflex sympathetic activation to inspiratory muscle loading is attenuated in females relative to males-Reference-Cited by-同舟云学术

Reflex sympathetic activation to inspiratory muscle loading is attenuated in females relative to males

Published:2024-07-01 Issue:1 Volume:327 Page:H28-H37
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Leahy Michael G.¹^ORCID,Busch Stephen A.¹,Thrall Scott F.²^ORCID,Hillen Sam J.¹,Sheel A. William¹^ORCID,Foster Glen E.²^ORCID

Affiliation:

1. School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada

2. Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Okanagan, British Columbia, Canada

Abstract

The blood pressure response to high levels of inspiratory muscle work is lower in females and occurs alongside a reduced sympathetic response. The reduced blood pressure and sympathetic response occur despite males and females performing similar levels of absolute inspiratory work. Our findings provide evidence that sex differences in the respiratory muscle metaboreflex are, in part, sympathetically mediated.

Funder

Canadian Government | Natural Sciences and Engineering Research Council of Canada

University of British Columbia Killam

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00133.2024

Reference35 articles.

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3. Threshold effects of respiratory muscle work on limb vascular resistance

4. Blood pressure and coeliac artery blood flow responses during increased inspiratory muscle work in healthy males

5. Sex differences in diaphragmatic fatigue: the cardiovascular response to inspiratory resistance