Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart

Author:

Kawagishi Hiroyuki12ORCID,Nakada Tsutomu3,Numaga-Tomita Takuro2,Larrañaga Maite4ORCID,Guo Ang5,Song Long-Sheng6,Yamada Mitsuhiko2

Affiliation:

1. Department of Biotechnology, Institute for Biomedical Sciences, Shinshu University, Matsumoto, Japan

2. Department of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan

3. Department of Instrumental Analysis, Research Center for Supports to Advanced Science, Shinshu University, Matsumoto, Japan

4. Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain

5. Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota

6. Division of Cardiovascular Medicine, Department of Internal Medicine and François M. Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa

Abstract

Although cardiomyocytes undergo proliferation in the early postnatal period, the regulatory mechanisms and physiological importance of this process have not been clarified. We found that the pharmacological and genetic depletion of gp130 or the neutralization of IL-6 with an antibody in preweaning mice resulted in significant impairment of cardiomyocyte proliferation, thinning of the myocardium, and systolic dysfunction of the left but not right ventricle by perturbing JAK/STAT3 signaling. Thus, the IL-6/gp130/JAK/STAT3 axis is crucial for the postnatal functional development of the left ventricle.

Funder

MEXT | Japan Society for the Promotion of Science

Nagano Prefecture

Aiba Works

Children's Cancer Association of Japan

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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