Affiliation:
1. From the Department of Cardiology, Boston Children’s Hospital, MA (Y.G., W.T.P.)
2. Harvard Stem Cell Institute, Cambridge, MA (W.T.P.).
Abstract
Maturation is the last phase of heart development that prepares the organ for strong, efficient, and persistent pumping throughout the mammal’s lifespan. This process is characterized by structural, gene expression, metabolic, and functional specializations in cardiomyocytes as the heart transits from fetal to adult states. Cardiomyocyte maturation gained increased attention recently due to the maturation defects in pluripotent stem cell–derived cardiomyocyte, its antagonistic effect on myocardial regeneration, and its potential contribution to cardiac disease. Here, we review the major hallmarks of ventricular cardiomyocyte maturation and summarize key regulatory mechanisms that promote and coordinate these cellular events. With advances in the technical platforms used for cardiomyocyte maturation research, we expect significant progress in the future that will deepen our understanding of this process and lead to better maturation of pluripotent stem cell–derived cardiomyocyte and novel therapeutic strategies for heart disease.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Reference198 articles.
1. Strategies for Improving the Maturity of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
2. Regulation of cardiomyocyte maturation during critical perinatal window [published online December 20, 2018].;Kannan S;J Physiol
3. Enhancement of human iPSC-derived cardiomyocyte maturation by chemical conditioning in a 3D environment
4. Advanced maturation of human cardiac tissue grown from pluripotent stem cells
5. Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine [published online February 3, 2020].;Karbassi E;Nat Rev Cardiol
Cited by
339 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献