Left ventricular diastolic dysfunction and exercise intolerance in obese heart failure with preserved ejection fraction

Author:

Samuel T. Jake1ORCID,Kitzman Dalane W.23,Haykowsky Mark J.4,Upadhya Bharathi2,Brubaker Peter5,Nelson M. Benjamin2,Hundley W.Gregory6,Nelson Michael D.17

Affiliation:

1. Department of Kinesiology, University of Texas at Arlington, Arlington, Texas

2. Section on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina

3. Section on Gerontology, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina

4. Faculty of Nursing, University of Alberta, Edmonton, Alberta, Canada

5. Department of Health and Exercise Science, Wake Forest University, North Carolina

6. Internal Medicine, Virginia Commonwealth University, Richmond, Virginia

7. Department of Bioengineering, University of Texas at Arlington, Arlington, Texas

Abstract

The mechanisms underpinning exercise intolerance in older obese patients with HFpEF have not been well characterized, however may be due in part, to impaired left ventricular diastolic function. Using a multimodal imaging approach to uncouple tissue deformation from atrial pressure, we found that relaxation is impaired in older obese patients with HFpEF, but only modestly correlates with their severely reduced peak exercise V̇o2. In contrast, the data show a much stronger relationship between elevated LV filling pressures and exercise intolerance in obese patients with HFpEF, refocusing future therapeutic priorities.

Funder

American Heart Association

HHS | National Institutes of Health

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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