Muscle metaboreflex control of left ventricular systolic function in heart failure with reduced ejection fraction-Reference-Cited by-同舟云学术

Muscle metaboreflex control of left ventricular systolic function in heart failure with reduced ejection fraction

Published:2023-08-01 Issue:2 Volume:135 Page:279-291
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Boyes Natasha G.¹,Nelson Michael D.²^ORCID,Palmero Canton Alberto²,Luchkanych Adam M. S.¹³,Khan M. Rafique¹,Bare Idris⁴,Haddad Tony⁴,Abdalla Sherif⁴,Marshall Rory A.³,Morse Cameron J.³,Zhai Alexander⁴,Haddad Haissam⁴,Marciniuk Darcy D.⁴,Karjala Geoffrey⁴,Olver T. Dylan³^ORCID,Tomczak Corey R.¹^ORCID

Affiliation:

1. College of Kinesiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

2. Department of Kinesiology, University of Texas at Arlington, Arlington, Texas, United States

3. Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

4. College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

Abstract

Stroke volume decreases and end-systolic volume increases during muscle metaboreflex activation in patients with heart failure with reduced ejection fraction (HFrEF), suggesting impaired contractile reserve during muscle metaboreflex activation in patients with HFrEF. Total peripheral resistance increases similarly during muscle metaboreflex activation in patients with HFrEF compared to controls, indicating normal levels of peripheral vasoconstriction during muscle metaboreflex activation in patients with HFrEF.

Funder

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Heart and Stroke Foundation of Canada

Saskatchewan Health Research Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00074.2023

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