The protective effect of remote ischemic conditioning is lost in patients with hypercholesterolemia-Reference-Cited by-同舟云学术

The protective effect of remote ischemic conditioning is lost in patients with hypercholesterolemia

Published:2022-11-01 Issue:5 Volume:323 Page:H1004-H1009
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Kövamees Oskar¹^ORCID,Mahdi Ali¹,Wodaje Tigist²,Verouhis Dinos¹,Brinck Jonas³^ORCID,Pernow John¹

Affiliation:

1. Division of Cardiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

2. Division of Cardiology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden

3. Division of Endocrinology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden

Abstract

We investigated the impact of hypercholesterolemia on the protective effect of RIC on ischemia-reperfusion injury in a well-characterized patient population with isolated hypercholesterolemia. The results show that the protective effect of RIC is absent in patients with hypercholesterolemia but is apparent in patients with hypercholesterolemic following treatment with lipid-lowering drugs. The results are of importance for the understanding of how comorbidities affect the therapeutic potential of RIC.

Funder

Stockholms Läns Landsting

Riksförbundet HjärtLung

Svenska Sällskapet för Medicinsk Forskning

Swedish Heart and Lung Association | HjärtLung Uppsala, Länsföreningen

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00464.2022

Reference31 articles.