Distinct time courses and mechanics of right ventricular hypertrophy and diastolic stiffening in a male rat model of pulmonary arterial hypertension-Reference-Cited by-同舟云学术

Distinct time courses and mechanics of right ventricular hypertrophy and diastolic stiffening in a male rat model of pulmonary arterial hypertension

Published:2021-10-01 Issue:4 Volume:321 Page:H702-H715
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Kwan Ethan D.¹,Vélez-Rendón Daniela²,Zhang Xiaoyan¹,Mu Hao¹,Patel Megh³,Pursell Erica¹^ORCID,Stowe Jennifer¹,Valdez-Jasso Daniela¹^ORCID

Affiliation:

1. Department of Bioengineering, University of California San Diego, La Jolla, California

2. Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois

3. College of Medicine, Texas A&M University, College Station, Texas

Abstract

Using a novel combination of hemodynamic and morphological measurements over 10 wk in a male rat model of PAH and a mathematical model of RV mechanics, we found that compensated systolic function was almost entirely explained by RV hypertrophy, but subsequently altered RV end-diastolic mechanics were primarily explained by passive myocardial stiffening that was not associated with significant collagen extracellular matrix accumulation.

Funder

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

National Science Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00046.2021

Reference61 articles.

1. Haemodynamic definitions and updated clinical classification of pulmonary hypertension