Affiliation:
1. Shu Chien-Gene Ley Department of BioengineeringUniversity of California, San Diego, La Jolla, California, United States
Abstract
Combining hemodynamic and morphological measurements from male, female, and ovariectomized female pulmonary arterial hypertension (PAH) rats revealed distinct adaptation mechanisms despite similar pressure overload. Males showed the most diastolic stiffening. Ovariectomized females had enhanced myocyte contractility and calcium transient upregulation. Ovary-intact females primarily responded with hypertrophy, experiencing milder passive myocardial stiffening and no changes in myocyte shortening. These findings suggest potential sex-specific pathways in right ventricular (RV) adaptation to PAH, with implications for targeted interventions.
Funder
American Heart Association
HHS | NIH | National Heart, Lung, and Blood Institute
HHS | NIH | National Institute of Biomedical Imaging and Bioengineering
National Science Foundation
Publisher
American Physiological Society
Cited by
1 articles.
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