Sympathetic determinants of resting blood pressure in males and females

Author:

Nardone Massimo1ORCID,Foster Monique2ORCID,O’Brien Myles W.34ORCID,Coovadia Yasmine5,Xie Shengkun6,Usselman Charlotte W.5ORCID,Kimmerly Derek S.3ORCID,Taylor Chloe E.2ORCID,Millar Philip J.1ORCID

Affiliation:

1. Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada

2. School of Health Sciences, Western Sydney University, Sydney, New South Wales, Australia

3. Division of Kinesiology, School of Health and Human Performance, Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada

4. School of Physiotherapy (Faculty of Health) and Division of Geriatric Medicine (Faculty of Medicine), Dalhousie University, Halifax, Nova Scotia, Canada

5. Cardiovascular Health and Autonomic Regulation Laboratory, Department of Kinesiology and Physical Education, McGill University, Montreal, Quebec, Canada

6. Global Management Studies, Ted Rogers School of Management, Toronto Metropolitan University, Toronto, Ontario, Canada

Abstract

In a sample of 191 normotensive young adults, we confirm that resting muscle sympathetic nerve activity is a poor predictor of resting blood pressure and now demonstrate that sympathetic baroreflex gain is associated with resting blood pressure in males but not females. In contrast, signal-averaged measures of sympathetic-blood pressure transduction are unrelated to resting blood pressure. These findings highlight sex differences in the neural regulation of blood pressure.

Funder

American Physiological Society

Canada Foundation for Innovation

Gouvernement du Canada | NSERC | RES'EAU-WaterNET

Ministère du Développement économique, de la Création d'emplois et du Commerce | Ontario Ministry of Research and Innovation

Ontario Ministry of Economic Development and Innovation

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Physiological Society

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