New insights into mechanisms of endothelial insulin resistance in type 2 diabetes

Author:

Padilla Jaume123ORCID,Manrique-Acevedo Camila234ORCID,Martinez-Lemus Luis A.256ORCID

Affiliation:

1. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri

2. NextGen Precision Health, University of Missouri, Columbia, Missouri

3. Harry S. Truman Memorial Veterans’ Hospital, Columbia, Missouri

4. Division of Endocrinology and Metabolism, Department of Medicine, University of Missouri, Columbia, Missouri

5. Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri

6. Center for Precision Medicine, Department of Medicine, University of Missouri, Columbia, Missouri

Abstract

Insulin resistance in the vasculature is a hallmark of type 2 diabetes (T2D), and blunting of insulin-induced vasodilation is its primary consequence. Individuals with T2D exhibit a marked impairment in insulin-induced dilation in resistance arteries across vascular beds. Importantly, reduced insulin-stimulated vasodilation and blood flow to skeletal muscle limits glucose uptake and contributes to impaired glucose control in T2D. The study of mechanisms responsible for the suppressed vasodilatory effects of insulin has been a growing topic of interest for not only its association with glucose control and extension to T2D but also its relationship with cardiovascular disease development and progression. In this mini-review, we integrate findings from recent studies by our group with the existing literature focused on the mechanisms underlying endothelial insulin resistance in T2D.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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