Insulin Resistance the Link between T2DM and CVD: Basic Mechanisms and Clinical Implications-Reference-Cited by-同舟云学术

Insulin Resistance the Link between T2DM and CVD: Basic Mechanisms and Clinical Implications

Published:2019-01-09 Issue:2 Volume:17 Page:153-163
ISSN:1570-1611
Container-title:Current Vascular Pharmacology
language:en
Short-container-title:CVP

Author:

Abdul-Ghani Muhammad A.¹,Jayyousi Amin²,DeFronzo Ralph A.¹,Asaad Nidal²,Al-Suwaidi Jassim²

Affiliation:

1. Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, United States

2. Cardio-Metabolic Institute, Hamad Medical Corporation, Doha, Qatar

Abstract

Insulin resistance (IR) is a cardinal feature of type 2 diabetes mellitus (T2DM). It also is associated with multiple metabolic abnormalities which are known cardiovascular disease (CVD) risk factors. Thus, IR not only contributes to the development of hyperglycemia in T2DM patients, but also to the elevated CVD risk. Improving insulin sensitivity is anticipated to both lower the plasma glucose concentration and decrease CVD risk in T2DM patients, independent of glucose control. We review the molecular mechanisms and metabolic consequences of IR in T2DM patients and discuss the importance of addressing IR in the management of T2DM.

Publisher

Bentham Science Publishers Ltd.

Subject

Cardiology and Cardiovascular Medicine,Pharmacology

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