Faster skin wound healing predicts survival after myocardial infarction

Author:

Becirovic-Agic Mediha12,Chalise Upendra12ORCID,Jung Mira3,Rodriguez-Paar Jocelyn R.12ORCID,Konfrst Shelby R.12,Flynn Elizabeth R.4,Salomon Jeffrey D.15,Hall Michael E.6ORCID,Lindsey Merry L.12ORCID

Affiliation:

1. University of Nebraska Medical Center, Omaha, Nebraska

2. Research Service, Nebraska-Western Iowa Health Care System, Omaha, Nebraska

3. Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany

4. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi

5. Division of Pediatric Critical Care, Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska

6. Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi

Abstract

Faster skin wound healers had more efficient cardiac healing after myocardial infarction (MI). Two plasma proteins at D3 MI, EAF1 and A2M, predicted MI death in 66% of cases. ApoD regulated both skin and cardiac wound healing in male mice by promoting inflammation. The skin was a mirror to the heart and common pathways linked wound healing across organs.

Funder

Swedish Society for Medical Research

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of General Medical Sciences

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Guidelines on the use of sex and gender in cardiovascular research;American Journal of Physiology-Heart and Circulatory Physiology;2024-01-01

2. Circulating microRNAs and cardiomyocyte proliferation in heart failure patients related to 10 years survival;ESC Heart Failure;2023-09-26

3. Skin wound healing as a mirror to cardiac wound healing;Experimental Physiology;2023-04-24

4. High-impact opportunities to address ischemia: a focus on heart and circulatory research;American Journal of Physiology-Heart and Circulatory Physiology;2022-12-01

5. The cardiac wound healing response to myocardial infarction;WIREs Mechanisms of Disease;2022-10-23

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