A canine model of chronic ischemic heart failure-Reference-Cited by-同舟云学术

A canine model of chronic ischemic heart failure

Published:2023-06-01 Issue:6 Volume:324 Page:H751-H761
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Khan Muhammad S.¹^ORCID,Smego Douglas²^ORCID,Ishidoya Yuki³,Hirahara Annie M.¹⁴,Offei Emmanuel¹⁴,Ruiz Castillo Martha S.¹⁴,Gharbia Omar¹^ORCID,Li Hui²,Palatinus Joseph A.¹³,Krueger Lauren⁵,Hong TingTing¹⁶,Hoareau Guillaume L.¹⁷^ORCID,Ranjan Ravi¹³⁴,Selzman Craig H.²^ORCID,Shaw Robin M.¹³⁴,Dosdall Derek J.¹²³⁴^ORCID

Affiliation:

1. Nora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah, Salt Lake City, Utah, United States

2. Division of Cardiothoracic Surgery, Department of Surgery, The University of Utah, Salt Lake City, Utah, United States

3. Division of Cardiovascular Medicine, Department of Internal Medicine, The University of Utah, Salt Lake City, Utah, United States

4. Department of Biomedical Engineering, The University of Utah, Salt Lake City, Utah, United States

5. Office of Comparative Medicine, The University of Utah, Salt Lake City, Utah, United States

6. Department of Pharmacology and Toxicology, College of Pharmacy, The University of Utah, Salt Lake City, Utah, United States

7. Department of Emergency Medicine, The University of Utah, Salt Lake City, Utah, United States

Abstract

The novel total left anterior descending devascularization (TLD) approach in a canine ischemic heart failure model limits collateral flow in the ischemic zone and provides excellent early survival and repeatable development of chronic ischemic heart failure in the canine heart. This work provides a consistent large animal model for investigating heart failure mechanisms and testing novel therapeutics.

Funder

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute on Aging

Nora Eccles Treadwell Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00647.2022

Reference40 articles.