Functional Cardiovascular Characterization of the Common Marmoset (Callithrix jacchus)

Author:

Klösener Lina123ORCID,Samolovac Sabine12ORCID,Barnekow Ina4,König Jessica4,Moussavi Amir24,Boretius Susann245ORCID,Fuchs Dieter6ORCID,Haegens Astrid7,Hinkel Rabea123ORCID,Mietsch Matthias12ORCID

Affiliation:

1. Laboratory Animal Science Unit, German Primate Center, Leibniz Institute for Primate Research, 37077 Göttingen, Germany

2. DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, 37075 Göttingen, Germany

3. Institute for Animal Hygiene, Animal Welfare and Farm Animal Behavior, University of Veterinary Medicine, 30173 Hannover, Germany

4. Functional Imaging Laboratory, German Primate Center, Leibniz Institute for Primate Research, 37077 Göttingen, Germany

5. Johann-Friedrich-Blumenbach Institute of Zoology and Anthropology, Georg August University, 37077 Göttingen, Germany

6. FUJIFILM VisualSonics Inc., 1114 AB Amsterdam, The Netherlands

7. Transonic Inc., Ithaca, NY 14850, USA

Abstract

Appropriate cardiovascular animal models are urgently needed to investigate genetic, molecular, and therapeutic approaches, yet the translation of results from the currently used species is difficult due to their genetic distance as well as their anatomical or physiological differences. Animal species that are closer to the human situation might help to bridge this translational gap. The common marmoset (Callithrix jacchus) is an interesting candidate to investigate certain heart diseases and cardiovascular comorbidities, yet a basic functional characterization of its hemodynamic system is still missing. Therefore, cardiac functional analyses were performed by utilizing the invasive intracardiac pressure–volume loops (PV loop) system in seven animals, magnetic resonance imaging (MRI) in six animals, and echocardiography in five young adult male common marmosets. For a direct comparison between the three methods, only data from animals for which all three datasets could be acquired were selected. All three modalities were suitable for characterizing cardiac function, though with some systemic variations. In addition, vena cava occlusions were performed to investigate the load-independent parameters collected with the PV loop system, which allowed for a deeper analysis of the cardiac function and for a more sensitive detection of the alterations in a disease state, such as heart failure or certain cardiovascular comorbidities.

Funder

German Center for Cardiovascular Research

Publisher

MDPI AG

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology

Reference111 articles.

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