Periostin promotes arterial calcification through PPARγ-related glucose metabolism reprogramming-Reference-Cited by-同舟云学术

Periostin promotes arterial calcification through PPARγ-related glucose metabolism reprogramming

Published:2021-06-01 Issue:6 Volume:320 Page:H2222-H2239
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Zhu Yi¹^ORCID,Ji Jing-Jing¹,Wang Xiao-Dong¹,Sun Xue-Jiao¹,Li Min¹,Wei Qin¹,Ren Li-Qun²,Liu Nai-Feng¹

Affiliation:

1. Department of Cardiology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, People’s Republic of China;

2. Department of Geriatrics, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, People’s Republic of China

Abstract

Periostin caused arterial calcification, overactivated glycolysis, and damaged OXPHOS. PPARγ agonists alleviated periostin-promoted arterial calcification and corrected abnormal glycolysis and unbalanced mitochondrial homeostasis. There exists a relationship between periostin and lactate in patients with CAC.

Funder

National Natural Science Foundation of China

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.01009.2020

Reference53 articles.

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