1. Departments of Molecular Pharmacology,
2. Pathology, and
3. Cardiovascular Medicine, Shinshu University School of Medicine, Nagano;
4. Discovery Research Laboratory II, Research and Development, Kissei Pharmaceutical Company, Limited, Azumino, Nagano;
5. Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Nagano;
6. Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical University, Iwate; and
7. Department of Cardiovascular Medicine, Shinshu University School of Health Science, Nagano, Japan