Protein tyrosine phosphatase receptor-ζ1 deletion triggers defective heart morphogenesis in mice and zebrafish-Reference-Cited by-同舟云学术

Protein tyrosine phosphatase receptor-ζ1 deletion triggers defective heart morphogenesis in mice and zebrafish

Published:2022-01-01 Issue:1 Volume:322 Page:H8-H24
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Katraki-Pavlou Stamatiki¹²,Kastana Pinelopi¹,Bousis Dimitris¹,Ntenekou Despoina¹,Varela Aimilia³,Davos Constantinos H.³,Nikou Sophia⁴,Papadaki Eleni⁴,Tsigkas Grigorios⁵^ORCID,Athanasiadis Emmanouil⁶^ORCID,Herradon Gonzalo⁷,Mikelis Constantinos M.¹⁸,Beis Dimitris²^ORCID,Papadimitriou Evangelia¹^ORCID

Affiliation:

1. Laboratory of Molecular Pharmacology, Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece

2. Zebrafish Disease Models Laboratory, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece

3. Cardiovascular Research Laboratory, Biomedical Research Foundation, Academy of Athens, Athens, Greece

4. Department of Anatomy–Histology–Embryology, Medical School, University of Patras, Patras, Greece

5. Department of Cardiology, Patras University Hospital, Rio, Greece

6. Systems Biology Center, Biomedical Research Foundation, Academy of Athens, Athens, Greece

7. Department of Pharmaceutical and Health Sciences, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain

8. Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas

Abstract

Protein tyrosine phosphatase receptor ζ1 (PTPRZ1) is expressed in fetal but not adult heart and seems to affect heart development. In both mouse and zebrafish animal models, loss of PTPRZ1 results in dilated left ventricle cavity, decreased ejection fraction, and fraction shortening, with no signs of cardiac hypertrophy. PTPRZ1 also seems to be involved in atrioventricular canal specification, outflow tract morphogenesis, and heart angiogenesis. These results suggest that PTPRZ1 plays a role in heart development and support the hypothesis that it may be involved in congenital cardiac pathologies.

Funder

State Scholarships Foundation

University of Patras

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00400.2021

Reference64 articles.

1. Development of the human heart

2. GATA transcription factors integrate Wnt signalling during heart development