GATA transcription factors integrate Wnt signalling during heart development-Reference-Cited by-同舟云学术

GATA transcription factors integrate Wnt signalling during heart development

Published:2008-10-01 Issue:19 Volume:135 Page:3185-3190
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Afouda Boni A.¹,Martin Jennifer¹,Liu Fei¹,Ciau-Uitz Aldo²,Patient Roger²,Hoppler Stefan¹

Affiliation:

1. Institute of Medical Sciences, Cell and Developmental Biology Research Programme, School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.

2. MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine,University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS,UK.

Abstract

Cardiogenesis is inhibited by canonical Wnt/β-catenin signalling and stimulated by non-canonical Wnt11/JNK signalling, but how these two signalling pathways crosstalk is currently unknown. Here, we show that Wnt/β-catenin signalling restricts cardiogenesis via inhibition of GATA gene expression, as experimentally reinstating GATA function overrides β-catenin-mediated inhibition and restores cardiogenesis. Furthermore, we show that GATA transcription factors in turn directly regulate Wnt11 gene expression, and that Wnt11 is required to a significant degree for mediating the cardiogenesis-promoting function of GATA transcription factors. These results demonstrate that GATA factors occupy a central position between canonical and non-canonical Wnt signalling in regulating heart muscle formation.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/135/19/3185/1534995/3185.pdf

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