Modulation of p66Shc impairs cerebrovascular myogenic tone in low renin but not low nitric oxide models of systemic hypertension

Author:

Hughes William E.1ORCID,Hockenberry Joe1,Miller Bradley1ORCID,Sorokin Andrey1ORCID,Beyer Andreas M.1ORCID

Affiliation:

1. Department of Medicine and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin

Abstract

We demonstrate that the modulation of p66Shc signaling impairs cerebral artery myogenic tone in a low renin model of hypertension. This impairment is dependent upon the genetic background, as modulated p66Shc signaling in Sprague-Dawley rats does not impair cerebral artery myogenic tone.

Funder

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Exploring the Gut–Mitochondrial Axis: p66Shc Adapter Protein and Its Implications for Metabolic Disorders;International Journal of Molecular Sciences;2024-03-25

2. Increased Ca2+-dependent intrinsic tone and arterial stiffness in mesenteric microvessels of hypertensive pregnant rats;Biochemical Pharmacology;2023-02

3. New developments in translational microcirculatory research;American Journal of Physiology-Heart and Circulatory Physiology;2022-12-01

4. Assessments of microvascular function in organ systems;American Journal of Physiology-Heart and Circulatory Physiology;2022-06-01

5. p66Shc signaling does not contribute to tubular damage induced by renal ischemia-reperfusion injury in rat;Biochemical and Biophysical Research Communications;2022-05

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