Cytokine storm in individuals with severe COVID-19 decreases endothelial cell antioxidant defense via downregulation of the Nrf2 transcriptional factor-Reference-Cited by-同舟云学术

Cytokine storm in individuals with severe COVID-19 decreases endothelial cell antioxidant defense via downregulation of the Nrf2 transcriptional factor

Published:2023-08-01 Issue:2 Volume:325 Page:H252-H263
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Rodrigues Daniel¹^ORCID,Machado Mirele R.¹,Alves Juliano V.¹,Fraga-Silva Thais F. C.²,Martins Ronaldo B.³,Campos Ligia C. B.⁴,Francisco Daniely F.⁴,Couto Ariel E. S.⁴,Bonato Vânia L. D.²,Arruda Eurico³,Becari Christiane⁴⁵^ORCID,Auxiliadora-Martins Maria⁴,Louzada-Júnior Paulo⁶,Costa Rafael M.¹⁷,Tostes Rita C.¹^ORCID

Affiliation:

1. Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil

2. Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil

3. Department of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil

4. Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil

5. Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil

6. Department of Clinical Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil

7. Academic Unit of Health Sciences, Federal University of Jatai, Jatai, Brazil

Abstract

We demonstrate that endothelial cell dysfunction in SARS-CoV-2-infected individuals is linked to decreased activity of the major antioxidant system regulator, the Nrf2 transcription factor. We provide evidence that this phenomenon relies on IL-6, an important cytokine involved in the pathophysiology of COVID-19. Our data support the view that Nrf2 activation is a potential therapeutical strategy to prevent oxidative stress and vascular inflammation in severe cases of COVID-19.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00096.2023

Reference52 articles.

1. The COVID-19 pandemic