Follicular oocyte as a potential target for severe acute respiratory syndrome coronavirus 2 infection

Author:

Yadav Pramod K.1ORCID,Pandey Ashutosh N.1ORCID,Premkumar Karuppanan V.1ORCID,Tiwari Meenakshi1ORCID,Pandey Ajai K.2ORCID,Chaube Shail K.1ORCID

Affiliation:

1. Cell Physiology Laboratory Department of Zoology Institute of Science Banaras Hindu University Varanasi Uttar Pradesh India

2. Department of Kayachikitsa Faculty of Ayurveda Institute of Medical Sciences Banaras Hindu University Varanasi Uttar Pradesh India

Abstract

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) was reported in December 2019 and rapidly became a pandemic as coronavirus disease 2019 (COVID‐19). Apart from other organs, presence of specific receptor angiotensin‐converting enzyme (ACE2) and corresponding proteases such as transmembrane serine protease 2, basigin and cysteine protease cathepsin L make follicular somatic cells as well as oocyte as potential targets for SARS‐CoV‐2 infection. The SARS‐CoV‐2 causes inflammation and hypoxia that generate reactive oxygen species (ROS) in critically ill patients. In addition, a large number of casualties and insecurity of life due to repeated waves of SARS‐CoV‐2 infection generate psychological stress and cortisol resulting in the further generation of ROS. The excess levels of ROS under physiological range cause meiotic instability, while high levels result in oxidative stress that trigger various death pathways and affect number as well as quality of follicular oocytes. Although, emerging evidence suggests that the SARS‐CoV‐2 utilises cellular machinery of ovarian follicular cells, generates ROS and impairs quality of follicular oocytes, the underlying mechanism of viral entry into host cell and its negative impact on the follicular oocyte remains poorly understood. Therefore, this review summarises emerging evidence on the presence of cellular machinery for SARS‐CoV‐2 in ovarian follicles and the potential negative impact of viral infection on the follicular oocytes that affect ovarian functions in critically ill and stressed women.

Publisher

Wiley

Reference122 articles.

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