A dynamic analysis of cardiovascular regulation using sinusoidal acceleration in dogs

Abstract

Control of cardiovascular function during time-dependent pooling of blood in the upper and lower body was studied in intact dogs (n = 5) and in dogs in which hearts had been surgically denervated (n = 5). The animal was positioned horizontally on a platform mounted on the arm of a centrifuge; rotation of the platform at one of nine rates with a period ranging from 3.3 min to 4 s exposed the subject to a sinusoidally varying force (+/- 2 g) that periodically translocated blood from the chest to the lower quarters and back again. The resulting oscillatory changes in arterial blood pressure (BP), cardiac output, stroke volume, heart rate (HR), and peripheral resistance (PR) were analyzed using a fast Fourier transform. Normal dogs were superior to cardiac-denervated dogs in minimizing arterial BP fluctuations, especially in the midfrequency range (i.e., approximately 0.032 Hz); after pharmacological alpha-, beta-, and muscarinic-receptor blockade, the BP oscillations were similar in the two groups. The unblocked denervated dogs regulated BP poorly primarily because of their inability to 1) make appropriately timed changes in HR and 2) minimize inappropriate oscillations in SV. Both groups of dogs in the unblocked state showed large appropriately timed PR fluctuations at the lower frequencies, which minimized BP oscillations; these became less optimally timed as acceleration frequency increased, thereby potentiating the natural disposition for BP to oscillate at the acceleration frequency. Afferent information from cardiac receptors did not appear to be essential for controlling this aspect of vascular function.